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Morphine side-effects
MORPHINE:
Myosis
Out of it (sedation)
Respiratory depression
Pneumonia (aspiration)
Hypotension
Infrequency (constipation, urinary retention)
Nausea
Emesis
CNS Effects of Morphine
SCREAMNT
S edation
C ough suppression/convulsions
R espiratory depression
E uphoria
A nalgesia
M yosis (but may cause mydriasis in doses causing asphyxia)
N ausea and vomiting
T runcal rigidity (especially with fentanyl)
Cocaine: cardiovascular effect
COcaine causes blood vessels to
COnstrict (unlike other local anesthetics which cause vasodilation).
Aminoglycosides:
common characteristics AMINO:
Active Against Aerobic gram negative
Mechanism of resistance are Modifying enzymes
Inhibit protein synthesis by binding to 30S subunit
Nephrotoxic
Ototoxic
Sulfonamides:
common characteristics SULFA:
Steven-Johnson syndrome/ Skin rash / Solubility low
Urine precipitation/ Useful for UTI
Large spectrum (gram positives and negatives)
Folic acids synthesis blocker (as well as synthesis of nucleic acids)
Analog of PABA
Diuretics:
groups "Leak Over The CAN":
Loop diuretics
Osmotics
Thiazides
Carbonic anhydrase inhibitors
Aldosterone inhibitors
Na (sodium) channel blockers
· Note: "leak" is slang for urination and "can" is slang for a toilet.
Gynacomastia, Drugs That Cause
"Some Drugs Create Awesome Knockers
S pironolactone
D igistalis
C isplatin
A lcohol
K etoconozole
Thalidomide:
effect on cancer cells "Thalidomide
makes the blood vessels hide":
Use thalidomide to stop cancer cells from growing new blood vessels.
Tuberculosis
"treatment If you forget your TB drugs, you'll
die and might need a PRIEST":
Pyrazinamide
Rifampin
Isoniazid (INH)
Ethambutol
STreptomycin
Warfarin:
interactions ACADEMIC QACS:
Amiodarone
Cimetidine
Aspirin
Dapsone
Erythromycin
Metronidazole
Indomethacin
Clofibrates
Quinidine
Azapropazone
Ciprofloxacin
Statins
Patent ductus arteriosus:
which prostaglandin keeps it open
kEEp opEn with prostaglandin E.
Carbamazepine (CBZ):
use CBZ:
Cranial Nerve V (trigeminal) neuralgia
Bipolar disorder
Zeisures
Drugs that act on microtubules.
"The MicroTubule Growth Voiding Chemicals":
Thiabendazole
Mebendazole
Taxol
Griseofulvin
Vincristine/ Vinblastine
Colchicine
Insulin
mixing regular insulin and NPH "Not Ready,
Ready Now":
Air into NPH
Air into Regular
Draw up Regular
Draw up NPH
Benzodiazepins:
3 members that undergo extrahepatic metabolism
"Outside The Liver":
Oxazepam
Temazepam
Lorazepam
These undergo extrahepatic metabolism and do not form active metabolites.
